Metronidazole and tinidazole in a single large dose for treating urogenital infections with Trichomonas vaginalis in men.
نویسنده
چکیده
Seventy-three men with urogenital trichomonal infection were treated with a single daily dose of 1 g tinidazole or 1.5 g metronidazole. Both treatments gave satisfactory results. Wives who were also infected with Trichomonas vaginalis, were less likely to have a recurrence of the infection after their husbands had been given either drug.
منابع مشابه
In vitro effect of tinidazole and furazolidone on metronidazole-resistant Trichomonas vaginalis.
Trichomonas vaginalis is a common sexually transmitted protozoan parasite. Although often considered simply a nuisance infection, T. vaginalis has been implicated in premature rupture of placental membranes and increases in the risk of acquiring human immunodeficiency virus. Metronidazole, a 5-nitroimidazole, is currently the drug of choice to treat T. vaginalis infection. Because some patients...
متن کاملIn vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.
The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of ...
متن کاملTrinidazole--a new preparation for Trichomonas vaginalis infections. I. Laboratory evaluation.
Tinidazole is a potent member of a new series of nitroimidazoles which are being used as antibiotics (Howes, Lynch, and Kivlin, 1970). The formula is: ethyl (2-(2-methyl-5-nitro-1-imidazolyl) ethyl) sulphone. Nothing has been published about the effect of tinidazole on strains of Trichomonas vaginalis isolated from clinical infections. A laboratory study of the relative efficacy of tinidazole a...
متن کاملTrichomonas vaginalis Antimicrobial Drug Resistance in 6 US Cities, STD Surveillance Network, 2009–2010
Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swa...
متن کاملStrain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles.
A strain of Trichomonas vaginalis (IR-78), recently isolated from a patient afflicted with recurrent symptomatic trichomoniasis, showed resistance to metronidazole, tinidazole, and nimorazole in vitro as well as in vivo. In a serial dilution test using cysteine monohydrochloride-peptone-liver infusion-maltose medium, T. vaginalis IR-78 was only resistant under aerobic conditions. Under anaerobi...
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ورودعنوان ژورنال:
- The British journal of venereal diseases
دوره 54 2 شماره
صفحات -
تاریخ انتشار 1978